The Female Fertility Guide

This Guide has been ongoing for about a year, regular breaks and returns to it. I’m now happy to release it. It is not in order of importance, I started with food because I did, no reason, sunlight is way down near the bottom but its importance could make it top. I want you to read it all but take your time, come back to it. Making sure your Fertility Health is good should be about fun, happiness and willingness. So first adopt a happy, easy going attitude to it and light heartedly follow this Guide to maximise your overall health and fertility. If you found your way to reading this, chances are you care deeply. About your body, about your future, about creating life… Naturally. Maybe you had bad advice, a lot of negativity or even trauma. You’re now safe here, I’ve compiled all this over many years. I’m pro-life, the world needs more good people. Life is a blessing, each one of us is important. Remember you’re here because of your parents fertility. You’re already part of family that made life.

Fertility is not a switch that flips on or off, it is a reflection of your overall vitality. Your hormones, your nervous system, your nourishment, your sleep, your stress levels, your sense of safety. When a woman feels supported, nourished and regulated, her body is far more likely to do what it was destined to do. The good news is the female body is profoundly intelligent and responsive. In many cases, fertility does not need to be forced. It needs to be supported, protected and brought back into balance. In this guide, I will cover the most fertility enhancing foods and micronutrients, evidence based supplements that support ovulation and egg quality, powerful superfoods used across cultures for reproductive vitality, and practical bio-hacks that improve hormonal signalling and mitochondrial health. My favourite part is to cover the ancient practices that calm the nervous system, restore rhythm and help the body feel safe enough to conceive. This is about creating the internal conditions where conception becomes more likely. Step by step. Before I start we have a…

Pre Guide: Before you start, it would be best to actually get a fertility test, so you know where you are, do you have PCOS. You can be tested for ovulation disorder, egg quantity (ovarian reserve) fallopian tube blockage, uterine abnormalities, hormonal imbalance and endometriosis – a bit harder to test but still. Why not take any guesswork out and then you can go forward knowing exactly what to focus on. Next I need you to do 2 weeks detox, some fasting before starting. Start with a clear slate. I have Guides for Detoxing Heavy Metals and Detoxing Micro-plastics. Take what you need from these, within 2-3 weeks you’ll be ready to start. The good news is you can boost fertility in this time too, just by clearing house you’re getting things working. Make your diet clean is this time, with some fasting. These obvious things must come into play before you start too. Maintain a healthy weight, being underweight or overweight can negatively impact fertility.

Consuming a whole food, organic diet while engaging in regular physical activity can help you achieve and maintain a healthy weight. I’m sorry to be boring but assuming you are of good health just calorie count and you’ll get your weight in balance, over-weight consume negative amount of calories until you reach a balanced weight based on your height. If you find this a challenge we have some things that can help in our Weight-loss Products section and have a Guide on Weight-loss. Also make your life a place of emotional well-being. Stress can interfere with ovulation and hinder your chances of conception. Find ways to be happy, balanced and peaceful, this is perhaps the most open for debate subject on earth, I know what works for me but then I’m a man and another unique human-being. So can I suggest here that this is your path, take a moment to think what would serve you in this area, what do you gravitate towards intuitively , what would you like to do or change to bring in balance, what needs to change or be added into your life? we also do have supplements and foods etc that support you on your path. Knowing your menstrual cycle can help you identify your fertile window, which is the best time to have sex to increase your chances of conception. All above covered, then let’s go starting with foods.

Food

I feel in simple terms your diet should be Keto, low sugar, low carbs. The human diet will be debated for the next million years, not something I want to get involved in anymore. I will focus on the foods that have the most nutrients supportive to fertility while avoiding those that hinder it. Without caring if it’s meat, fruit, carbs or veg. Apple Cider Vinegar can be incredible before main meals, it doesn’t have to be daily but it helps. Never have any sugar on an empty stomach, you’ve obviously got to reduce sugars out of your diet to as best you can. All these things great, but ultimately it’s about avoiding bad food / edible products more. It’s about what you don’t eat, did all our super fertile ancestors eat some secret plant picked in the mountains? you know they didn’t in fact often their diet in many parts of the world wasn’t great, maybe the water wasn’t either. But there was no junk food around, no pollution. So live clean, eat clean, as best you can. If it has a label, don’t buy it, if it tastes amazing… question why. I loved Thai food, travelled there ate it daily, discovered loaded with MSG. Indian food, loaded with sugar, seed oils. We know how bad Chinese food is, we know what is in junk food. Food should taste nice, and ideally cooked with love, by yourself or someone that loves you. Everything is energy. I want to state whether you’re a carnivore or vegan protein should be 2g per kg of your body weight, so if not eating meat, clean vegan protein. Make sure your calories are at slightly above maintenance level for your height. You want to be slim but no way skinny. Right let’s do foods, no order here I’ll just start with Seafoods.

Seafoods

Seafoods are incredible in female fertility, it supports hormonal signalling, egg membrane health, anti-inflammatory balance and thyroid stability. I would suggest you average for 2 – 3 servings fatty fish weekly and one serving shellfish weekly (if tolerated). Then I suggest you avoid or limit swordfish, king mackerel, tilefish and bigeye tuna as these are high in mercury and can impair egg quality. Shrimp, herring, cod and white fish all good, but we are focusing on the best here.

Sardines: Sardines are small, low-mercury fish that are exceptionally rich in omega-3s while also providing calcium and vitamin D when eaten with the bones. Their selenium content helps protect developing follicles from oxidative damage, which is important because eggs are particularly sensitive to inflammation and environmental stress. Sardines are also highly bioavailable in nutrients, meaning the body absorbs and uses what they provide very efficiently.

Wild Salmon: Wild salmon is one of the most powerful fertility-supporting foods because it delivers high levels of DHA, an omega-3 fat that helps maintain the integrity and flexibility of egg cell membranes. Healthy cell membranes are crucial for fertilisation and embryo development. Salmon also provides vitamin D, which plays a key role in ovulation and hormone regulation, and selenium, which helps protect eggs from oxidative stress. Its anti-inflammatory properties support a healthier uterine environment for implantation.

Oysters: One of the most concentrated food sources of zinc, a mineral essential for proper ovulation, egg maturation, and hormone balance. Zinc supports follicle development and plays a role in healthy progesterone production after ovulation. Oysters also provide iron and B12, which are important for oxygen delivery to reproductive tissues and maintaining a healthy uterine lining.

Mussels: Mussels stand out for their iron and B12 content, both critical for women who experience heavy cycles or low iron stores. Iron deficiency has been linked to ovulatory challenges, and adequate levels are necessary to support implantation and early pregnancy development. Mussels also provide protein and trace minerals that support metabolic and hormonal stability.

Atlantic Mackerel: Extremely rich in omega-3 fatty acids, offering potent anti-inflammatory benefits that support egg quality and hormone signalling. Chronic low-grade inflammation can interfere with ovulation and implantation, and omega-3s help restore balance. Mackerel also contains iodine, which supports thyroid function — a key regulator of menstrual cycles and fertility.

Dulse: Dulse is rich in Iodine / Potassium / Iron and Trace minerals. It supports thyroid-driven ovulation and may help women with low iodine intake, especially those avoiding dairy or seafood. You could swap out for Lugols Iodine but as a food it’s a great little option.

Meat & Dairy

Protein is foundational for female fertility because every reproductive hormone, enzyme, and signalling molecule in the body is built from amino acids. Adequate protein supports ovulation, progesterone production after ovulation, and the development of a healthy uterine lining for implantation. It helps stabilise blood sugar which is critical for balanced insulin levels, directly influencing ovarian function and egg maturation. The eggs are living cells that require strong structural integrity, antioxidant support, and efficient mitochondrial energy production, all processes that depend on sufficient amino acids. Inadequate protein intake can contribute to hormonal irregularity, weak ovulation, and impaired embryo development. For women that will conceive, consistent high-quality protein at each meal helps create a metabolically stable, hormone-supportive environment. But the focus isn’t just protein in meat, it’s Iron (for ovulation and implantation) Zinc (for egg maturation) B12 (for cell division) Choline (for embryo development) Healthy fats (for hormone production) Iodine (for thyroid regulation). Quality matters, organic, free to roam, from conscious farms. Skip supermarkets, find local farms, meet the farmers, it all helps. Nutrient density matters more than quantity in meat and here are the strongest options. At least have 1.5g for every kg of body weight daily.

Grass-Fed Beef: One of the most powerful fertility meats. It provides highly absorbable heme iron, zinc critical for ovulation and supports follicle development and progesterone balance. Beef is rich in Vitamin B12 and a complete protein. Iron deficiency is strongly linked to ovulatory infertility, and beef is one of the most effective ways to restore levels.

Lamb: Lamb is a clean meat and it supports hormone production because reproductive hormones are built from cholesterol and fats. Because lamb is often pasture-raised, it has a very rich fatty acid profile. It is rich in Iron / Zinc / Vitamin B12 and healthy saturated fats

Chicken: Especially thighs as they contain more iron and zinc than breast, B vitamins and Collagen-supportive amino acids. They support blood building and connective tissue health, which is important for uterine lining integrity. Chicken Liver is extremely nutrient dense. The Liver gives a massive hit of B12, Folate in natural form, then Iron and choline. It supports egg development and early embryo growth. But not too much Liver as the Vitamin A from liver can be harmful in excess. Once or twice a week is good.

Eggs: They contain choline, a nutrient many women are deficient in and one that is critical for egg development, DNA methylation, and early embryo growth. The yolk also provides B12, folate (in natural form), selenium, iodine and high-quality protein, all essential for ovulation and proper hormone signalling. Reproductive hormones like oestrogen and progesterone are built from cholesterol. Only free-range, pasture-raised eggs, I drive 25 minutes to get mine. They’re higher in omega-3 fatty acids and fat-soluble vitamins, that improved fatty acid profile may help reduce inflammation, important for egg quality and implantation. The nutrients are in the yolk, 1 or 2 whole eggs per day will be a strong foundation food.

Full-Fat Cheese: Eat in moderation and unpasteurised only. These quality cheeses provide bio-available Calcium / Vitamin K2 / Protein and Saturated fats for hormone production. Best used as part of a whole-food pattern, not ultra-processed cheese products. Forget supermarkets as a place for unpasteurised cheese, I used to drive up to Suffolk to this cool farm shop just to get some. Expect to be looking in farm shops and farmers markets for these. Plus you then don’t support the machine, instead our beloved farmers here in the UK.

Whole Milk: Provides Iodine / Protein and Fat-soluble vitamins. Some observational data suggests low-fat dairy may be associated with ovulatory issues, while full-fat versions appear beneficial. Milk is a hard one, I say you must go for raw milk when you have it, not everyone tolerates milk. I’m just sharing.

Bone Broth: This in my opinion is one of the most foundational foods for female fertility because it rebuilds the physical and biochemical terrain that reproduction depends on. It is rich in collagen, glycine, proline, and glutamine, which directly support the integrity of the uterine lining, cervical tissue, and the entire reproductive tract, creating a stronger and more receptive environment for implantation. Its high mineral content, including calcium, magnesium, phosphorus, and trace elements, feeds the endocrine system and supports the enzymatic processes behind hormone production. Glycine in particular helps regulate blood sugar and lowers inflammation, both critical for stable ovulation and progesterone balance, while also supporting deep sleep, where much of the body’s hormonal repair occurs. At the same time, bone broth strengthens the gut lining, which is essential for proper nutrient absorption and the recycling of hormones via the liver and microbiome. When used consistently, it does not act like a quick fix but instead restores the structural and metabolic foundation that allows fertility to function at its highest level.

Fruits / Vegetables & Nuts

When I say below about a cup daily or something, I don’t mean of each every day, that would be too much, just cycle between the fruits, the veg because they don’t have the sugar content you’re safe for those daily.

Avocado: Provides monounsaturated fats required for oestrogen and progesterone synthesis. Improves insulin sensitivity and supports cervical mucus production. You can eat 1 whole avocado daily but just be aware thats a lot of calories, so off-set it against less of something else.

Blueberries: High in anthocyanins that protect ovarian follicles from oxidative damage and support mitochondrial function in the egg. You can have 1 cup daily.

Pomegranate: Pomegranate polyphenols improve uterine blood flow and protect eggs from oxidative stress. It enhances nitric oxide production, improving endometrial receptivity.

I suggest 200ml of pure juice or half a Pomegranate daily. The other half next day, if that isn’t obvious.

Broccoli: Supports oestrogen detoxification via sulforaphane. Helps regulate hormone balance and reduce oestrogen dominance. 1 cup lightly steamed daily.

Beetroot: Increases nitric oxide production, improving ovarian and uterine circulation. Supports implantation. You can eat 1 medium beet daily or 100 ml juice.

Sweet Potato: High in beta-carotene which supports progesterone production and corpus luteum function after ovulation. 1 medium sweet potato daily.

Asparagus: Rich in folate and glutathione. Supports egg quality and reduces oxidative stress during follicle maturation. Safe to eat 1 cup every day of the per week.

Walnuts: High in omega-3 ALA and antioxidants. Improve egg membrane integrity and reduce ovarian inflammation. Small handful daily.

Almonds: Provide vitamin E and healthy fats that protect ovarian tissue and support cervical mucus. Small handful daily.

Pumpkin Seeds: Rich in zinc and iron. Support ovulation and egg maturation. 1–2 tablespoons daily.

Brazil Nuts: Extremely high in selenium. Supports thyroid function and ovarian antioxidant protection. I have to mention if you eat Brazil’s do not take a selenium supplement, you can easy cover Selenium with Brazil Nuts 3 or 4 nut would give you the exact 200mcg of Selenium I recommend. But levels fluctuate, some people therefore prefer supplementing. Either way Selenium is essential.

Chia Seeds: This tiny seeds provide omega-3 and fibre for hormone balance and insulin regulation. I think it’s best to soak them, take 1–2 tablespoons daily.

Water & other Drinks

I really could do an article called Water & Fertility, thats how important it is. Actually I could apply that title to anything in health, Water & Eyesight, Water & Heart Health etc. Anyway, every single reproductive process depends on proper cellular hydration, not just “not being thirsty.” Egg development, cervical mucus production, blood flow to the uterus, and hormone signalling all rely on fluid balance at a cellular level. If hydration is even slightly off, the body quietly deprioritises reproduction. Forget fixed “2 litres a day” rules. The more accurate target is 40ml per kg of body weight as a baseline, then I would suggest you increase further with exercise, heat, caffeine, or high protein intake

For most women, this lands roughly between 2.5 – 3 litres daily, but I think more key is consistency, not random spikes. Plain water alone is not optimal. Without minerals, it can dilute electrolytes and actually reduce cellular hydration. Add a pinch of Celtic Sea Salt to 1 or 2 glasses daily. Personally I also recommend putting a drop of Fulvic Acid Minerals in every glass, or if you are drinking a litre bottle 2 to 3 times daily add like 5 drops per litre. Now I get it sound like the solution to water and fertility is buy 2 of our products. You could totally succeed with a decent mineral water. However most of the time people I meet are using a gravity filter, RO or some other filter taking tap water and cleaning it. But if you live near a spring you’re winning. Expect to add some minerals for full benefits of water. I not as well that Fulvic improves fluid absorption into cells, not just a passing through. Stable hydration supports stable hormones.

Action

• Start the day with 500ml on waking to reset hydration after sleep
• Add minerals to the water you’re drinking.
• Drink steadily through the day, not in large bursts.
• Reduce intake 1 to 2 hours before bed to protect sleep quality

Avoid

• Tap water and plastic bottled water.
• Excess caffeine without compensating fluids
• Constant sipping without minerals
• Overhydration that leads to clear, mineral-depleted urine

Done properly, water is not just “supportive” it directly upgrades the environment where ovulation, fertilisation, and implantation happen. Proper hydration directly affects cervical mucus, which is essential for sperm survival and transport. Poor hydration leads to thicker, less fertile mucus, even if everything else is “perfect.” Blood volume is heavily dependent on hydration. Better hydration equals better circulation to the ovaries and a thicker, more nourished endometrial lining. The Teas below don’t worry you don’t need all, it’s just to give you a supportive choice, I’ve tried most below and rare is the one I enjoy.

Nettle Leaf Tea: Deep mineralisation for the reproductive system. Extremely rich in bioavailable iron, magnesium, calcium, and silica, nettle feeds the exact mineral pathways required for hormone production and blood building. Strong, well-mineralised blood directly translates to a thicker, more receptive endometrial lining, which is critical for implantation. It also supports adrenal stability, helping regulate the stress response, which in turn stabilises progesterone levels in the luteal phase. Over time, it strengthens overall vitality rather than just tweaking cycles, making the whole reproductive system more resilient and less prone to disruption. This is not a light herbal tea, it behaves more like a deep nutritional infusion that rebuilds the body from the ground up.

Red Raspberry Leaf Tea: Uterine strength and tone. This herb has a direct affinity for the uterus, improving muscle tone and function so that the womb is not weak or sluggish but responsive and well-supplied. It contains fragarine, a compound known to support efficient uterine contractions and improve blood flow, which helps create a more optimal implantation environment. It also has a gentle regulatory effect on the endocrine system, helping smooth out irregular cycles over time. By strengthening the luteal phase and supporting proper shedding and rebuilding of the lining, it sets up a more predictable and fertile rhythm. This is foundational if the goal is a strong, stable, and receptive uterus. So many powers to this actually, it’s in our Fluoride & Chlorine Detox Tea.

Ginger Tea: Circulation and anti-inflammatory power. Ginger is one of the simplest but most effective ways to increase blood flow throughout the body, including directly to the ovaries and uterus. This improved circulation means better oxygenation, better nutrient delivery, and a more active reproductive environment. At the same time, it reduces systemic inflammation, which is a silent disruptor of ovulation and hormone signalling. It also improves insulin sensitivity, which is critical for women dealing with blood sugar instability or PCOS-related issues. The combined effect is a warmer, more nourished reproductive system that functions more efficiently. Simple, but very physiologically active.

Spearmint Tea: Androgen control. Spearmint is one of the few natural substances shown to actively lower elevated testosterone levels in women. This makes it particularly powerful for those dealing with PCOS or symptoms of androgen excess such as irregular cycles or poor ovulation. By reducing androgens, it helps restore a more balanced hormonal environment where ovulation can occur more consistently. It also improves the conditions in which follicles develop, leading to healthier egg maturation. This is not a vague hormonal “support”, it creates a measurable shift in androgen levels, which can be a key unlock for fertility in the right context.

Green Tea: Egg protection and metabolic regulation. Green tea is rich in EGCG, a powerful antioxidant that helps protect the ovarian reserve from oxidative damage over time. This preservation of egg quality is critical, especially with age. It also improves insulin sensitivity and supports metabolic health, both of which are tightly linked to hormone balance and ovulation. Additionally, it supports healthy follicle development by reducing inflammation and oxidative stress within the ovarian environment. It has a mild fat-burning effect, which can further support hormonal balance in those carrying excess weight. However, it should be used in moderation, as excessive intake can interfere with folate absorption, which is essential for fertility. Yes you can totally use Matcha I just said Green Tea, Matcha same benefits.

Shatavari Tea: I considered listing this in herbs, as in taking as a supplement, but I have been told the tea is very nice. It’s a female reproductive tonic from Ayurvedic medicine. Shatavari is one of the most targeted herbs for female reproductive health, traditionally used to nourish and build what Ayurveda calls the reproductive tissue layer. It supports healthy oestrogen levels without forcing them, helping to create balance rather than spikes. It also improves cervical mucus quality, which is essential for sperm survival and successful fertilisation. Beyond that, it enhances the overall receptivity of the uterus, increasing the likelihood of successful implantation. Its action is both nourishing and regulatory, making it particularly powerful when used consistently over time. This is a true fertility tonic, not just a short-term intervention. If you are sipping too much go for a supplement instead.

Dandelion Root Tea: Liver optimisation for hormone control. The liver is responsible for processing and clearing excess hormones, especially oestrogen, and dandelion root directly enhances this function. By improving liver detox pathways, it helps prevent oestrogen dominance, which can disrupt ovulation and cycle regularity. It also stimulates bile flow, which is essential for the proper breakdown and elimination of hormones. When the liver is working efficiently, hormones stay in balance rather than accumulating or fluctuating unpredictably. This creates a more stable internal environment for ovulation and implantation. If the liver is sluggish, fertility quietly declines, and this is one of the simplest ways to correct that bottleneck.

Coffee (done properly): Some women would choose to avoid totally, but I am a great believer in happiness and good feelings being the most important thing here. I mean this one is nuanced, but powerful when used right. High-quality coffee, used strategically, can enhance metabolism and increase circulation, including blood flow to reproductive organs. It also boosts dopamine signalling, which plays a role in the hormonal cascade that governs ovulation. In small amounts, it can improve insulin sensitivity and mental focus, indirectly supporting hormonal stability. However, this only works when intake is controlled. Excess coffee raises cortisol, which directly interferes with progesterone and overall reproductive balance. Keep it to one small, clean coffee per day, ideally earlier in the day, and avoid entirely if stress levels are high or cycles are irregular. Used correctly, it enhances physiology. Overused, it becomes a fertility disruptor.

Pomegranate Juice: Ovarian and uterine antioxidant protection. Pomegranate is one of the most potent fertility-supporting foods when it comes to protecting egg quality. It is loaded with polyphenols that shield developing eggs from oxidative stress, which is one of the main drivers of declining fertility. It also enhances blood flow to the uterus, helping to build a thicker, more nutrient-rich endometrial lining. Through its effects on nitric oxide pathways, it improves vascular function, meaning better delivery of hormones and nutrients where they are needed most. It has also been linked to improvements in the follicular environment, where eggs mature. This directly protects and enhances one of the most critical factors in fertility, which is egg quality.

Supplements

My favourite part because just wow changes. Here’s the lowdown on supplements you could introduce with the above and healthy, balanced lifestyle and diet. I’m starting with CoQ10 now I want to make it clear I could write pages on each of these supplements on why they help, so in the interest of space I have massively condensed each. After you get the program started it would be helpful to give yourself confidence in each and further read on why they are so powerful. This will reinforce your trust in the journey..

CoQ10 (Ubiquinol Form)

CoQ10 is a critical component of the mitochondrial electron transport chain. Inside every cell, mitochondria generate ATP, which is the usable energy currency required for all cellular processes. CoQ10 acts as an electron carrier between Complex I and Complex III, allowing efficient ATP production. Egg cells contain the highest mitochondrial density of any cell in the human body. An oocyte requires enormous amounts of energy during maturation, spindle formation, chromosomal alignment, fertilisation and early embryonic division. Unlike many other cells, eggs rely almost entirely on mitochondrial ATP during these stages. As women age, mitochondrial function declines, and this directly increases the risk of poor egg quality and chromosomal errors. Age-related aneuploidy is strongly linked to mitochondrial dysfunction. Supplementing CoQ10 restores mitochondrial electron transport efficiency, improves ATP output and reduces oxidative damage within the oocyte. In women over 35, clinical studies have shown improved ovarian response and better embryo quality when CoQ10 is used prior to IVF. It is one of the most evidence-supported interventions for age-related egg quality decline. It improves how well existing mitochondria function. It optimises performance of the mitochondria already present in the egg. The CoQ10 dosage is 600mg daily (Ubiquinol preferred). We have a liposomal version at the website.

PQQ

Pyrroloquinoline Quinone works at a different level to CoQ10. Rather than directly participating in ATP production, PQQ stimulates mitochondrial biogenesis through activation of pathways such as PGC-1 alpha and CREB. This promotes the creation of new mitochondria and enhances cellular antioxidant defence systems. So CoQ10 improves the efficiency of existing mitochondria. PQQ can increase mitochondrial number and resilience. Together, they target both mitochondrial performance and mitochondrial renewal. This dual approach addresses one of the central biological drivers of age-related fertility decline, which is mitochondrial deterioration within the oocyte. That is why this combination is a serious mitochondrial strategy. PQQ 20mg daily, run for minimum 90 days, optimal would be 6 months. Take both with fat containing meals. Stop PQQ once pregnant

Myo-Inositol & D-Chiro-Inositol

Myo-inositol improves insulin sensitivity / Restores proper FSH signalling in granulosa cells / Supports follicle maturation / Improves oocyte cytoplasmic quality / Reduces excessive ovarian androgen production. It helps the ovary respond properly to hormonal signals. Even in non-PCOS women, subtle insulin dysregulation can impair egg quality. Myo-inositol improves intracellular signalling efficiency, which supports better follicular development. It also improves: Oocyte quality in IVF settings / Ovulation regularity / Ovarian environment oxidative balance. That is why it is considered first-line in PCOS.

D-chiro-inositol is a downstream conversion product of myo-inositol. It plays a stronger role in: Glycogen synthesis / Insulin-mediated glucose storage / Reducing excess androgen production. Too much D-chiro-inositol in the ovary can be harmful. In PCOS, the ovary over-converts myo into D-chiro locally, leading to imbalance. That is why ratio matters. In healthy ovarian tissue, the physiological plasma ratio of: Myo-inositol to D-chiro-inositol is approximately 40:1. This ratio appears optimal for: Proper FSH signalling / Oocyte maturation / Hormonal balance. Clinical studies show the 40:1 ratio produces better ovulation and pregnancy rates than either alone.

Non-PCOS women Myo-inositol can still improve oocyte quality, but the effect is smaller than in PCOS. It becomes more powerful if: Fasting insulin is elevated / There is subtle insulin resistance / There is history of miscarriage /There are mild cycle irregularities. To be clear again this is the situation for you to take this combo – if you have PCOS / High fasting insulin / Elevated testosterone / Irregular ovulation / High LH to FSH ratio / Age over 35 or really want to optimise egg quality

Myo-inositol – 2000mg twice daily, so 4000mg daily. D-chiro-inositol 50mg twice daily total 100mg daily. Take morning and evening. Run for a minimum

3 months. Follicles recruited today started developing about 90 days ago. Optimal would be 6 months pre-conception. when pregnant stop D-chiro and reduce or stop inositol unless needed for glucose control.

Vitamin D3 & Vitamin K2

Vitamin D receptors are present in: Ovarian granulosa cells / the endometrium placenta and pituitary. This tells you it is directly involved in reproductive signalling. It regulates: Anti-Müllerian hormone expression / Follicle development / FSH responsiveness / Ovulatory signalling / Progesterone receptor sensitivity in the uterine lining. Adequate vitamin D improves the endometrium’s response to progesterone, which strengthens implantation potential. Successful implantation requires controlled immune tolerance. Vitamin D helps reduce excessive inflammatory or autoimmune reactions that may interfere with embryo implantation. Low D3 is associated with: Poor IVF outcomes / Lower pregnancy rates / Increased miscarriage risk / Menstrual irregularities / PCOS severity. Now the positive as optimised vitamin D supports: Regular ovulatory cycles / Healthier follicular maturation / Improved luteal phase signalling / Better implantation environment Vitamin D increases calcium absorption. Vitamin K2 ensures that calcium is directed into bones and teeth rather than soft tissues. K2 plays additional roles relevant to fertility: Supports vascular health, including uterine blood flow / Reduces inappropriate soft tissue calcification / Works synergistically with vitamin D in gene regulation / Supports mitochondrial function indirectly. The endometrium requires healthy microvascular circulation for implantation. K2 helps maintain vascular integrity.

Sunlight is the most natural source of vitamin D. UVB exposure on bare skin triggers endogenous production of cholecalciferol. If living in a sunny climate, get at least 30 minutes of midday sun exposure on arms and legs daily. Darker skin requires longer exposure. Indoor living, latitude and seasonal variation make supplementation necessary. Blood testing is the only reliable way to confirm adequacy. But I never have, my personal belief is simple… The Sun is the One, don’t burn, get as much as you can. But you decide. Scientifically optimal fertility blood range is 40 to 60ng per ml. Some reproductive clinics aim for 50 to 60 ng per ml. For preconception optimisation: Vitamin D3 4000IU daily. If blood levels are below 30 ng per ml: 10,000 IU daily for 8 to 12 weeks, then retest /break. Vitamin K2 100 to 200 mcg daily. Preferably MK-7 form for longer half life. This is what we have, both together in one supplement or we have high dose 10k iu soft gels with Olive Oil, a super supplement that one. Take this supplement with a fat-containing meal. Use for a minimum of 3 months before attempting conception. Continue through preconception and early pregnancy under medical guidance. We have a both the high dose Vitamin D3 and the D3 K2 combination at Ancient Purity.

Omega-3 Fatty Acids (EPA | DHA)

EPA and DHA integrate into cell membranes, increasing membrane fluidity and improving receptor signalling. Egg cells rely on flexible, stable membranes for fertilisation. DHA supports mitochondrial membrane function, improving ATP production inside the oocyte. Omega-3 fatty acids regulate prostaglandin balance, which influences ovulation timing and uterine contractions. Reduced inflammatory signalling supports endometrial receptivity during implantation. Omega-3 intake also improves insulin sensitivity, stabilising ovarian hormone output. Improved membrane structure and inflammatory balance enhance ovulation quality and implantation stability. Choose Krill Oil, it’s the most clean and go for 1000mg daily but don’t skip getting seafoods in the week as well, see my list above. We have super clean Artic Krill at the website and sorry the 60 soft gel jar will give you a month supply

MSM Organic Sulphur

MSM supplies organic sulphur, required for glutathione synthesis, connective tissue structure, and phase II liver detoxification. Glutathione protects ovarian follicles from oxidative stress generated during egg maturation. Oxidative stress accelerates follicular ageing and reduces egg quality. Sulphur compounds support the sulfation pathway in the liver, which regulates estrogen metabolism and prevents estrogen dominance. Balanced oestrogen metabolism supports regular ovulation and proper endometrial preparation. MSM also contributes to collagen formation, strengthening uterine lining integrity and structural resilience during implantation. Reducing systemic inflammation and improving antioxidant capacity creates a more stable hormonal environment for ovulation and implantation. All that and I firmly believe there is way deeper effects, we actually supply our MSM Organic Sulphur to a fertility clinic thats using it as part of its protocols. Back in 2014 I would say MSM is good for this or that, now I think it’s everything. Everything gets better with MSM Organic Sulphur. But on this one supplement, do not buy MSM, they just don’t work. This MSM Organic Sulphur we have, is magic, it works, it gets results. The amount is way more than a typical MSM, you’re looking at 8g twice daily. It’s available at the website.

Zinc

Zinc directly affects follicle-stimulating hormone (FSH) and luteinising hormone (LH) receptors. These receptors are what allow your ovaries to “hear” the signals from your brain to mature eggs and trigger ovulation. Without adequate zinc, these receptors can function less efficiently, leading to irregular cycles or weaker ovulatory signals. It is vital for DNA transcription and chromosomal alignment during oocyte (egg) development. Proper DNA transcription ensures that the egg has the correct genetic instructions, while accurate chromosomal alignment prevents errors that can lead to aneuploidy (eggs with the wrong number of chromosomes). This is a major determinant of egg quality and the likelihood of successful fertilisation. During oocyte maturation, cells must divide precisely. Zinc stabilises spindle formation and other cellular machinery, ensuring that division is orderly. This reduces the risk of genetic mistakes and supports robust egg development. After ovulation, the egg leaves the follicle, which transforms into the corpus luteum to produce progesterone. Progesterone prepares the uterine lining for implantation. Zinc supports this hormone production, helping create a receptive environment for an embryo. It also helps balance immune activity in the uterine lining. A well-modulated immune environment allows the embryo to implant without triggering excessive inflammatory responses, which can otherwise block implantation or cause early miscarriage. Can you see how vital this is? Optimised zinc improves egg quality, ensures precise hormonal signalling, and supports a balanced uterine environment, all of which increase chances of conception. There are lots of Zincs I would suggest 30mg of Citrate, it’s easy on the stomach, especially when you are going to possibly take a lot of supplements. Our Zinc is Citrate, and it’s not the way round that I am recommending Citrate because we have that one. It’s we have that one because it is the best one and it contains a little Copper making it ideal for longer use. Find it in store or at Ancient Purity site.

L – Carnitine

L-carnitine is far more important for female fertility than most people realise, especially after 35. Its primary role is transporting long-chain fatty acids into mitochondria so they can be burned for ATP production. Without carnitine fatty acids cannot efficiently enter mitochondria, so reduced ATP output. Egg cells are extremely energy dependent. During: Follicle maturation / Spindle formation / Chromosome segregation / Fertilisation / Early embryonic cleavage. Mitochondrial ATP demand is enormous, if mitochondrial fatty acid oxidation is inefficient, egg quality declines. With age: Mitochondrial efficiency declines / Fatty acid metabolism becomes less flexible / Oxidative stress increases / Ovarian tissue accumulates damage. Carnitine helps: Improve mitochondrial beta oxidation / Increase ATP production / Reduce oxidative stress / Stabilise mitochondrial membranes / Improve ovarian metabolic environment. In PCOS specifically, carnitine improves: Ovulation rate / Insulin sensitivity / Hormonal balance / Oocyte quality

There are human trials showing improved ovulation and pregnancy rates in women with PCOS using carnitine. Even in non-PCOS women, it supports egg mitochondrial energy production. Acetyl-L-Carnitine (ALCAR) I best for: Mitochondrial function / Brain and cellular energy / Crossing blood brain barrier / Anti-ageing support. So I think it is best for egg mitochondrial support. As there are loads of Carnitines, get ALCAR. Women with PCOS will really benefit from carnitine. A systematic review and meta-analysis involving women with PCOS revealed that carnitine supplementation ranging from 250mg to 3000 mg daily for up to 90 days significantly improved ovulation and pregnancy rates, while reducing BMI and insulin resistance. Take 2000mg daily if PCOS go for 3000mg. Run for a minimum 90 days, ideally 6 months

Folate (5-MTHF)

Methylfolate drives one-carbon metabolism, the pathway responsible for DNA methylation, nucleotide synthesis, and chromosomal replication. Oocyte maturation involves intense DNA repair and chromosomal alignment. Adequate methylfolate reduces chromosomal segregation errors and supports genetic stability. During the first days after fertilisation, the embryo undergoes rapid cell division. Folate availability directly influences this replication process. Proper methylation also regulates gene expression in early embryonic development. Optimised folate levels strengthen egg DNA integrity and support early embryo viability. Take 400 – 800mcg daily depending on age, or if you have genetic issue with 5MTHF, these cases definitely 800mcg. Methylfolate is the fully bio-available form and you’ll find it at Ancient Purity

Iron

Iron is essential for oxygen transport via haemoglobin and supports mitochondrial respiration within ovarian follicles. Developing eggs require oxygen for ATP production during maturation. Iron deficiency reduces oxygen delivery to both follicles and the endometrium. Adequate iron levels support the development of a thick, vascularised uterine lining capable of sustaining implantation. Iron also supports thyroid enzyme activity, indirectly influencing ovulation regulation. Restored iron levels improve follicle oxygenation and strengthen endometrial growth during the luteal phase. 25–65 mg elemental iron daily for 2–3 months when levels are low. Remember if meat heavy diet this is probably not needed.

Vitamin E (Full Spectrum)

Vitamin E is a lipid-soluble antioxidant that protects polyunsaturated fatty acids within ovarian cell membranes from oxidation. Oxidative damage compromises egg quality and mitochondrial efficiency. Vitamin E stabilises cellular membranes and supports blood vessel dilation in reproductive tissues. Improved microcirculation increases oxygen and nutrient delivery to the endometrium. Vitamin E also supports progesterone synthesis by protecting luteal cells from oxidative damage. Enhanced membrane protection and circulation improve egg integrity and implantation conditions. It must be full spectrum Vitamin E, as full spectrum delivers all 8 natural forms exactly as nature intended, providing both tocopherols and tocotrienols together so your body can fully recognise and absorb them. Most Vitamin E supplements fail because they are biologically incomplete from the start. Remove the confusion, don’t bother trying cheap isolated Vitamin E sups, I’m afraid we have discontinued it due to slow sales, but find a reputable one.

Vitamin C

Vitamin C supports collagen synthesis in the uterine lining, strengthening structural integrity for implantation. It acts as a primary water-soluble antioxidant protecting ovarian follicles from reactive oxygen species generated during ovulation. Vitamin C enhances iron absorption, improving haemoglobin production and oxygen transport. It also supports progesterone production during the luteal phase by stabilising corpus luteum function. Improved antioxidant protection and endometrial structure support ovulation stability and embryo attachment. You could go high and easy with Liposomal form, budget with the ascorbic acid, capsules with L-ascorbate, sorry there’s so many options on Vitamin C. Kakadu Plum is the ultimate food option by far. Whatever you choose I’d take at least 3 grams daily, spread it across the day, do not take a single dose, Vitamin C works powerfully when spread out. All the Vitamin C options are at the site. For ease choose the Liposomal one and mix into 4 drinks daily.

Nitric Oxide (NO) Supplement

This is a signalling molecule that relaxes blood vessels. Increased NO improves circulation to the ovaries and uterus, ensuring that follicles receive nutrients, oxygen, and hormones efficiently during maturation. Better blood flow to the ovaries means follicles get more of the building blocks they need for healthy egg growth. This can improve egg quality and ovulation potential. Enhanced uterine circulation helps endometrial thickness and oxygenation. A well-perfused endometrium is more receptive for implantation and can support early embryo development. Nitric oxide modulates vascular tone in the uterus, helping the tiny blood vessels expand and contract optimally. This creates a stable and supportive environment for embryo attachment, reducing the risk of early implantation failure. I think this is so important for overall fertility, also vital for heart health, but just on fertility we can safely say NO Improves nutrient delivery to eggs, strengthens follicle development, enhances uterine receptivity and supports embryo implantation.

A classic option would be 5g of L-Arginine, cycled, but I think much cleaner and effective is our Hawthorn Elixir it was designed for natural nitric oxide boosting, remember natural is powerful the ingredients aren’t to be fancy natural, clean herbs but powerful game changers. Hawthorn helps blood vessels relax and flow smoothly. Better systemic circulation means better delivery of blood, oxygen and nutrients to the ovaries and uterus, which can support follicle development and endometrial receptivity. The Beetroot is rich in natural compounds that feed the nitric oxide pathway, helping vessels dilate and improving blood flow. This is the same mechanism used by L arginine but in a whole food form. The Cayenne gives a mild circulation stimulant that gently increases blood flow and warmth in tissues, helping peripheral circulation without overstimulation. The Hibiscus is high in antioxidants and traditionally used to support vascular elasticity and healthy blood flow, which can help maintain smooth uterine and ovarian perfusion. the Hibiscus gives some Vitamin C but you will also take it from the Kakadu Plum or other Vitamin C supplement these antioxidants protect nitric oxide from oxidative breakdown.

N-Acetyl Cysteine (NAC)

N-Acetyl Cysteine (NAC) is one of the most interesting antioxidants for reproductive health because it provides cysteine, a key building block required for the production of glutathione, one of the body’s most important intracellular antioxidants. Glutathione helps maintain the redox balance within ovarian cells and protects cellular proteins, membranes and mitochondria from oxidative damage. This is particularly relevant to developing follicles, where mitochondrial energy production and protection from oxidative stress are essential during maturation. NAC also has metabolic effects, including support for insulin sensitivity and glucose regulation, which may be especially relevant to women with PCOS or metabolic dysfunction. Research in PCOS has investigated NAC’s potential to support more regular ovulation, improve hormonal and metabolic parameters and create a more favourable environment for follicular development. NAC’s antioxidant and anti-inflammatory properties also make it particularly interesting during the later stages of follicular maturation, when maintaining a stable cellular environment is important for oocyte development. Dose: 600–1,200 mg daily (some research protocols use up to 1,800 mg).

Selenium

Selenium is a trace mineral with an unusually important role in reproductive biology because it forms part of several selenium-dependent enzymes involved in antioxidant defence, thyroid metabolism and cellular protection. Glutathione peroxidases, for example, rely on selenium to help neutralise damaging reactive oxygen species, providing protection for ovarian and reproductive tissues. Selenium is also required for deiodinase enzymes that help convert thyroid hormone T4 into the more biologically active T3. Because thyroid signalling interacts closely with reproductive hormone function, maintaining adequate selenium status supports the wider endocrine environment in which normal ovulation and reproductive function take place. Selenium-dependent antioxidant systems may also help protect follicular cells and the developing oocyte from oxidative stress. Within the uterus, maintaining healthy antioxidant and thyroid-related pathways may support the cellular environment required for normal endometrial development. Selenium therefore sits at an interesting intersection between thyroid function, antioxidant protection, cellular energy and reproductive physiology. Dose: 200mcg daily, we have it at Ancient Purity

NMN (Nicotinamide Mononucleotide)

NAD+ is essential for mitochondrial energy production and is also involved in DNA repair, cellular signalling and the activity of sirtuins, proteins that regulate cellular stress responses and metabolism. NAD+ levels decline with age in many tissues, and researchers have become particularly interested in whether restoring NAD+ availability could improve mitochondrial function in ageing reproductive cells. The oocyte is exceptionally dependent on healthy mitochondria because it requires large amounts of ATP to mature properly, maintain chromosome organisation and support the earliest stages following fertilisation.

The potential fertility relevance of NMN therefore centres on cellular ageing rather than simply hormone levels. Experimental research has found that increasing NAD+ availability can influence mitochondrial function, oxidative stress and cellular resilience in ovarian tissue. In animal models, NAD+-boosting approaches have produced particularly interesting findings, including improvements in oocyte quality and aspects of reproductive ageing. NMN may also support the activity of sirtuins and other NAD+-dependent pathways involved in maintaining mitochondrial integrity and responding to DNA damage. This has led to significant interest in NMN as a potential strategy for protecting reproductive cells from some of the cellular consequences associated with ageing.

NMN targets a fundamental requirement of the egg: energy and mitochondrial efficiency. As oocytes age, mitochondrial dysfunction and increased oxidative stress become increasingly important factors affecting cellular quality. By increasing the availability of NAD+, NMN is being investigated as a way of supporting the biochemical systems that keep mitochondria functioning and cells resilient. The fertility research is still predominantly preclinical rather than established human fertility evidence, but the underlying biology has made NAD+ restoration one of the more interesting emerging areas of research into ovarian ageing and oocyte quality. Dose: I would actually go for the full longevity dose of 1g daily, you get so many other benefits just go for that.

Lugols Iodine

Iodine is one a quiet, foundational that determines whether female fertility functions smoothly or subtly falls apart. It’s been a staple supplemental fix all at Ancient Purity since 2010. It is required to produce thyroid hormones, these act like a master timing system for the entire reproductive axis. When iodine is sufficient, the thyroid sends clear, stable signals that help regulate ovulation, support a strong luteal phase, and prepare the body for pregnancy. Ovulation is highly sensitive to thyroid status. If iodine is low, thyroid hormone production drops, cycles become irregular, ovulation may be delayed or inconsistent, and in some cases it may not occur at all. Even when ovulation does happen, the quality of that cycle can be compromised.

One of the most important downstream effects is on progesterone. A healthy luteal phase depends on proper thyroid signalling. Without enough Iodine, progesterone output can weaken, shortening the luteal phase and reducing the chances of successful implantation. This is often an overlooked reason why conception doesn’t happen, even when everything else appears normal. It also becomes critically important the moment conception occurs. In the earliest stages of pregnancy, before the baby can produce its own thyroid hormones, it relies entirely on the mother’s supply. These hormones are essential for early brain and nervous system development. Even mild iodine insufficiency at this stage can affect this process. It’s not just about avoiding deficiency, but ensuring precision. Regular cycles, strong ovulation, stable progesterone, and healthy early development all depend on it. We supply Lugols Iodine, I suggest starting with a small dose and see how well you respond, I keep saying this about nearly all these but… Another possible game changer.

Choline

Choline supports cell membrane integrity and methylation pathways required for egg DNA stability. It is critical in early embryonic neural development and placental formation. Many women consume less than half the required intake. Choline also contributes to the production of phosphatidylcholine, a major structural component of cell membranes, which is particularly important as an egg undergoes rapid cellular changes during maturation and early embryo development. It supports one-carbon metabolism alongside folate and vitamin B12, helping maintain the biochemical environment required for DNA synthesis and normal cell division. Adequate choline intake has also been associated with healthier pregnancy development and may support the placenta’s ability to transport nutrients and maintain normal cellular function. Dosage: 450–900 mg daily (from food plus supplementation).

Magnesium Glycinate

Magnesium regulates insulin sensitivity, cortisol balance, and progesterone production. It stabilises the nervous system, supports ovarian blood flow, and assists estrogen detoxification pathways. Adequate magnesium improves sleep, which directly impacts reproductive hormone rhythms. Magnesium is also involved in hundreds of enzymatic reactions, including those responsible for energy production, DNA and RNA synthesis, cellular signalling and glucose metabolism. Good magnesium status may therefore support the high energy demands of developing follicles and the metabolic processes involved in ovulation. Its role in glucose regulation is particularly relevant because insulin resistance can interfere with normal ovarian function and reproductive hormone signalling. Magnesium also supports normal muscle and blood-vessel function, helping maintain healthy circulation throughout the reproductive system. Dosage: 300-400 mg daily, best to use our Liposomal Magnesium Glycinate at Ancient Purity

Alpha-Lipoic Acid (ALA)

ALA improves mitochondrial function and insulin sensitivity. It reduces oxidative stress within ovarian follicles and supports egg energy metabolism. Particularly useful in women with metabolic dysfunction or PCOS. ALA works in both water- and fat-soluble environments and can participate in the regeneration of other antioxidant systems, giving it a broad role in cellular protection. This is relevant to the ovary because developing follicles and oocytes have substantial energy requirements, while excessive oxidative stress can interfere with mitochondrial activity and cellular signalling. By supporting glucose metabolism and insulin sensitivity, ALA may also help create a more favourable metabolic environment for ovulation, particularly where insulin resistance is present. Research in PCOS has additionally investigated its potential effects on menstrual regularity, ovulation and metabolic parameters, making it particularly interesting for women whose fertility is affected by metabolic dysfunction. Dosage: 300–600 mg daily.

Melatonin

Melatonin acts as a potent antioxidant within the ovarian follicle. Follicular fluid naturally contains melatonin, protecting the egg from oxidative stress during maturation. Supplemental melatonin has been investigated for its ability to improve the follicular antioxidant environment, reduce oxidative damage and support mitochondrial function during oocyte maturation. The mitochondria inside an egg provide much of the energy required for maturation, fertilisation and the earliest stages of embryo development, making mitochondrial protection particularly relevant to reproductive biology. Melatonin may also influence ovarian steroid production and the local environment surrounding the developing follicle. Its close relationship with the body’s circadian system gives it an additional role in maintaining normal biological timing, including signalling involved in reproductive hormone regulation. These combined antioxidant, mitochondrial and circadian effects are why melatonin has attracted considerable interest in research into oocyte quality and assisted reproduction. Dosage: 2–3 mg nightly.

B Vitamins

A clean, food based B-Complex provides the full spectrum of B vitamins required for hormone regulation, ovulation control, and energy metabolism within the ovaries. Vitamin B6 regulates prolactin levels and supports progesterone production during the luteal phase. Adequate progesterone is required to stabilise the uterine lining after ovulation. Vitamin B2 and B3 support mitochondrial energy production during follicle maturation. Vitamin B12 and folate drive DNA synthesis and chromosomal replication in the developing oocyte. Vitamin B5 supports adrenal function, which directly influences sex hormone output. Vitamin B1 supports glucose metabolism, stabilising insulin levels that impact ovarian function. Balanced B-vitamin intake improves estrogen metabolism through liver methylation pathways, reducing excess circulating estrogen and supporting hormonal rhythm. Proper methylation also supports egg DNA integrity and early embryonic cell division. Dosage: 1 tablet daily, we have an awesome food-state B Multi thats very popular.

Evening Primrose Oil (EPO)

Evening Primrose Oil provides gamma-linolenic acid (GLA), an omega-6 fatty acid involved in prostaglandin production. Prostaglandins regulate cervical mucus production, uterine muscle tone, and ovulatory signalling. Increased cervical mucus improves sperm transport through the cervix during the fertile window. Adequate prostaglandin balance supports coordinated uterine contractions that assist sperm movement toward the fallopian tubes. GLA also influences inflammatory balance. Controlled inflammatory signalling is required for ovulation and proper endometrial preparation. Improved fatty acid balance enhances cervical fluid quality and supports uterine tissue responsiveness during the follicular phase. Evening Primrose Oil is taken during the first half of the menstrual cycle because prostaglandin activity shifts after ovulation. Dosage: 1,500 mg up to twice daily (3,000 mg total daily) from day 1–14 of the menstrual cycle. Discontinue after ovulation.

Multi Vitamin & Mineral Complex

A comprehensive preconception multi vitamin corrects micronutrient deficiencies that directly impair ovulation, follicle development, hormone production, and implantation. Ovarian follicles require continuous DNA replication, mitochondrial energy production, and precise hormone signalling to mature properly. Iodine regulates thyroid hormones, which control ovulation timing and progesterone output. Selenium protects ovarian tissue from oxidative damage and supports thyroid conversion of T4 to active T3. Zinc regulates follicle-stimulating hormone and luteinising hormone activity, both required for egg maturation and ovulation. Vitamin B12 drives cellular replication during oocyte maturation and early embryo division. Methylfolate supports DNA synthesis and chromosomal integrity. CoQ10 enhances mitochondrial ATP production inside the egg, improving energy availability during maturation. Correcting these deficiencies stabilises cycles, strengthens ovulation quality, and supports early embryo development from the first cell division. Dosage: 2 capsules daily providing approximately 150 mcg iodine, 200–400 mcg methylfolate, 8–15 mg zinc, 100–200 mcg selenium, 2–5 mcg B12, and 100–200 mg CoQ10. Remember if you add in our Multi Vitamin check the dosage compare to the other things you’re using, like Zinc, Selenium etc.

Probiotics | Must contain Lactobacillus

Probiotics work through the gut, the immune system, and crucially, the vaginal microbiome. Lactobacillus is the dominant beneficial bacteria in a healthy female reproductive tract. Producing lactic acid, keeping the vaginal environment slightly acidic. This acidity is not random. It is protective. It prevents harmful bacteria and pathogens from taking hold, creating the right conditions for sperm survival and successful conception. When Lactobacillus levels are strong, the environment is stable, clean, and supportive. When they are low, harmful microbes can increase, inflammation can rise, and this can interfere with sperm function, implantation, and overall fertility.

A healthy gut microbiome supports hormone balance, particularly the recycling and regulation of oestrogen. It also strengthens immune tolerance, which is critical when the body needs to accept and support a developing embryo. The key point is this: not all probiotics are equal. For female fertility, they must contain Lactobacillus strains. Without them, you are missing the very bacteria that define a healthy reproductive environment. Done properly, probiotics help create the internal conditions are naturally supported. Ancient Purity’s Synergy Probiotics contain Lactobacillus and are ideal for this.

DHEA

Dehydroepiandrosterone is a hormone precursor produced mainly by the adrenal glands and can be converted into androgens and oestrogens. Its relevance to fertility comes from the role androgens play in early follicle development. The theory is that increasing ovarian androgen activity may make developing follicles more responsive to FSH, potentially improving the recruitment and development of follicles in women with diminished ovarian reserve or previous poor response to ovarian stimulation. At the follicular level, DHEA-derived androgens interact with androgen receptors in ovarian cells and may increase FSH sensitivity. Androgen signalling can also influence communication between granulosa cells and the developing oocyte, with proposed involvement of pathways such as IGF-1 that regulate follicular growth. In other words, the interest isn’t in creating new eggs, but in potentially improving the environment and responsiveness of follicles that are already present. Randomised trials and meta-analyses have reported improvements in markers such as antral follicle count (AFC) and basal FSH, and earlier studies also reported increases in eggs retrieved and pregnancy rates.

Superfoods

I want you to consider using many of the below in a smoothie, maybe with a base of Cacao, Coconut Oil and some mineral water. Being real here you could be doing this whole protocol for a year if you are in a low state of fertility right now. So my purpose here is also cycling, shaping things around so you get maximum successful impact from each supplement or superfood, herb etc.

Maca:

Maca has a long history of traditional use for female reproductive health and is particularly interesting for its potential effects on the hypothalamic–pituitary–ovarian axis. Rather than acting like a conventional hormone, maca appears to influence reproductive signalling and may support more balanced communication between the brain, pituitary gland and ovaries. This makes it especially interesting for women looking to support regular ovulatory function, healthy libido and reproductive resilience during periods of physical or psychological stress. Maca also contains macamides and other bioactive compounds with antioxidant and metabolic activity, which may help protect cells from oxidative stress and support cellular energy production. By supporting overall endocrine and metabolic function, maca may contribute to a healthier environment for follicular development and reproductive function. Its effects are generally viewed as supportive rather than as directly supplying reproductive hormones. Dose: 2–3 grams daily of gelatinised maca powder.

Royal Jelly:

Royal jelly is an unusually concentrated natural food containing proteins, peptides, fatty acids, B vitamins, minerals and other bioactive compounds. Its reproductive interest comes partly from its antioxidant and anti-inflammatory activity, which may help protect ovarian tissue and developing oocytes from oxidative stress. Royal jelly also contains 10-HDA and other distinctive compounds that have demonstrated biological effects on cellular signalling and metabolism. Research has explored its influence on ovarian activity, reproductive tissues and hormone-related pathways, with experimental studies suggesting potential benefits for follicular development and reproductive function. Its combination of amino acids, lipids and micronutrients also provides raw materials needed for rapidly dividing cells, making it particularly interesting in the preconception period when follicular development and early embryonic processes depend heavily on adequate cellular nutrition. Human fertility evidence remains limited, but the biological profile of royal jelly makes it a particularly interesting reproductive-support ingredient. Dose: 500–1,000 mg fresh or freeze-dried daily.

Bee Pollen:

Bee pollen provides a broad nutritional spectrum including amino acids, essential minerals, vitamins, polyphenols, carotenoids and other plant compounds. For reproductive health, its main attraction is the combination of antioxidant protection and nutritional support it provides to metabolically active tissues. Ovarian follicles require substantial amounts of energy and nutrients as they develop, and the antioxidants in pollen may help maintain a healthier cellular environment by countering oxidative stress. Its zinc, selenium and other micronutrients contribute to normal hormone production, cellular repair and antioxidant defence, while its amino acids provide building blocks for proteins involved in cellular growth and signalling. Bee pollen also contains a diverse range of polyphenols that may support healthy inflammatory and metabolic pathways. Together, these properties make it an interesting whole-food approach to supporting ovarian nutrition and general reproductive health. Dose: 1–2 teaspoons daily.

Spirulina & Chlorella:

Spirulina and chlorella provide concentrated nutrition that can support the metabolic demands of reproductive tissues. Spirulina supplies protein, iron, carotenoids, B vitamins and antioxidant compounds, including phycocyanin, which has been extensively studied for its antioxidant and cellular-protective properties. Iron is particularly relevant to reproductive health because adequate iron status supports haemoglobin production and oxygen transport throughout the body, including the tissues involved in follicular development and the uterine lining. Chlorella adds protein, chlorophyll, iron, folate and a range of micronutrients, providing additional nutritional support for rapidly dividing cells. Rather than viewing chlorella simply as a "detox" product, its strongest fertility relevance is its nutrient density and antioxidant profile. Together, spirulina and chlorella can provide broad nutritional support for energy metabolism, antioxidant defence and healthy cellular function during the reproductive cycle. Dose: 3–5 grams daily.

Goji Berries:

Goji berries are rich in carotenoids, polyphenols and other antioxidant compounds that can help protect cells against oxidative stress. This is relevant to ovarian health because developing follicles and oocytes are metabolically active and particularly dependent on efficient mitochondrial energy production. Goji’s antioxidant compounds may help preserve cellular structures and mitochondrial function while supporting the body’s natural defence systems. The berries also provide vitamin C, iron, fibre and a range of phytochemicals that contribute to overall nutritional status. Their polysaccharides have attracted particular scientific interest for their potential antioxidant and metabolic effects. Healthy liver metabolism is also important for normal handling of circulating hormones, making a nutrient-rich diet containing antioxidant foods such as goji a useful part of an overall reproductive-support strategy. Dose: 20–30 grams dried berries daily.

Kakadu Plum:

Kakadu plum is one of the richest natural food sources of vitamin C, making it particularly valuable for antioxidant and connective-tissue support. Vitamin C contributes to collagen formation, which is important for maintaining healthy connective tissue throughout the reproductive system, and it also enhances the absorption of non-haem iron from plant foods. Adequate vitamin C provides antioxidant protection to cells exposed to oxidative stress, including ovarian tissue and developing follicles. Kakadu plum also contains polyphenols and other phytochemicals that contribute to its antioxidant capacity beyond vitamin C alone. Supporting iron absorption is particularly useful for women whose diets are predominantly plant-based, while maintaining strong antioxidant defences helps protect cellular structures during the reproductive cycle. Dose: 1 gram 3 times daily.

Sea Buckthorn:

Sea buckthorn provides an unusually broad combination of fatty acids, carotenoids, vitamin E and other antioxidant compounds. Its omega-7 content is particularly distinctive, while its vitamin E and carotenoids contribute to protection against oxidative damage to cell membranes. Healthy cell membranes are fundamental to reproductive biology because ovarian cells, oocytes and endometrial tissue rely on precise membrane signalling and lipid composition. The fatty acids in sea buckthorn may also support healthy mucosal tissues, making it of interest for maintaining the quality of cervical and vaginal tissues. Its antioxidant compounds provide additional support for cellular resilience, while its lipid profile supplies structural components needed for normal cell function. Together, these properties make sea buckthorn an interesting nutritional option for supporting reproductive tissues and overall cellular health. Dose: 1,000–2,000 mg oil daily.

Black Sesame Seeds:

Black sesame seeds combine minerals, healthy fats, protein, lignans and antioxidant compounds that can provide broad nutritional support for reproductive function. They are particularly rich in calcium, magnesium, iron and zinc, minerals involved in cellular energy production, hormone-related enzymes, DNA synthesis and normal reproductive function. Their lignans are plant compounds that interact with estrogen metabolism and may influence how the body processes and circulates estrogenic compounds. Sesame also provides vitamin E and other antioxidants that help protect cellular membranes from oxidative stress. The combination of minerals, healthy fats and plant compounds makes black sesame especially useful as a nutrient-dense food for supporting follicular development, normal ovulatory function and the nutritional demands of the endometrium. Dose: 1–2 tablespoons freshly ground daily.

Shatavari:

Shatavari (Asparagus racemosus) has traditionally been used in Ayurvedic medicine as a woman’s reproductive and hormonal support herb, and modern research is beginning to investigate some of these traditional applications. Its steroidal saponins and other plant compounds are thought to contribute to its biological activity, with research examining potential effects on ovarian function, reproductive hormones and the endometrium. A recent randomized controlled trial in women with PCOS found that standardized shatavari extract increased endometrial thickness and reduced psychological stress compared with placebo, adding some interesting human evidence to the traditional use of the herb. Shatavari has also been investigated for supporting female sexual wellbeing, with recent controlled research finding improvements in measures of sexual function and satisfaction. Its combination of traditional reproductive use, potential effects on ovarian and endometrial function, and emerging clinical research makes it one of the more interesting herbs to include in a female fertility-support programme. Dose: 500–1,000 mg standardized extract daily.

Vitex (Chasteberry): One of the most targeted and powerful herbs for regulating female reproductive hormones, but its strength comes from how it works. It does not act like oestrogen or progesterone directly. Instead, it works at the brain level, specifically the hypothalamus and pituitary, which control the entire hormonal cascade. Its main action is increasing luteinising hormone while helping normalise prolactin. This has a downstream effect of improving progesterone production after ovulation, which is critical for a strong luteal phase and successful implantation. Many women with fertility issues are not lacking ovulation itself, but have weak progesterone afterwards, and this is exactly where Vitex is most effective. It is particularly powerful in cases of:

• Short or weak luteal phase
• Irregular cycles
• PMS linked to progesterone deficiency
• Mildly elevated prolactin interfering with ovulation

Over time, it helps bring the cycle into a more natural rhythm rather than forcing a quick hormonal spike. That is why it often takes a few cycles to fully show its effect, but the changes are more stable and sustainable. One important point is that Vitex is not universal. If a woman already has high oestrogen or certain types of hormonal imbalance, it can feel like it is “not working” or even make things feel worse. This is because it is shifting upstream signals, not just boosting one hormone. Used in the right context, it is one of the closest things to a natural regulator of the menstrual cycle and luteal strength. Misused, it can push things slightly off. It is a precision tool, not a blanket fertility herb.

Sunlight & Fertility

Sunlight is one of the simplest and most overlooked fertility tools because it does far more than help the body produce vitamin D. Natural light is one of the main signals that sets the body’s circadian clock, helping regulate sleep, melatonin and the timing of hormone production. This matters for female fertility because the reproductive system is tightly connected to the brain’s circadian and hormonal systems. Regular exposure to natural daylight helps keep these rhythms properly timed, supporting the hormonal environment involved in the menstrual cycle and ovulation. Morning sunlight is particularly valuable. Bright natural light entering the eyes early in the day provides the brain with a strong signal that the day has begun, helping establish the timing of the sleep-wake cycle and the release of melatonin later in the evening. Melatonin is not simply a sleep hormone. It is involved in reproductive physiology and interacts with the hormonal systems controlling LH, FSH and sex steroids. Maintaining a strong day-night rhythm therefore gives the reproductive system a more consistent biological timetable.

Sunlight also provides the body’s natural route to vitamin D production. Scroll back up to supplements to see why Vit D is so essential for female fertility. The bigger picture is that modern life can provide the opposite of what the reproductive system evolved around: little natural light during the day and large amounts of artificial light at night. Spending time outdoors during daylight, particularly earlier in the day, while keeping evenings darker, helps reinforce the natural light-dark rhythm. For female fertility, sunlight therefore belongs alongside sleep, exercise and nutrition as a basic environmental signal that helps keep the body’s hormonal and metabolic systems properly timed. A simple fertility-focused approach is to get outside and expose yourself to natural daylight every morning, spend additional time outdoors during the day, and reduce bright artificial light late at night. Combined with adequate vitamin D from sunlight, food or supplementation where appropriate, this creates a powerful daily foundation for circadian health, hormonal regulation and reproductive function.

Sleep

Obvious but often not taken seriously enough. Good quality, consistent sleep is a major factor that supports reproductive health. During sleep, the body is carrying out essential hormonal, metabolic and cellular processes, and when sleep becomes consistently disrupted, those systems can be affected. Poor or insufficient sleep can disrupt the normal rhythm of cortisol, the hormone involved in the body’s response to stress. The reproductive system does not operate independently from this system. The brain, hypothalamus, pituitary gland and ovaries communicate constantly to regulate the hormones that control the menstrual cycle and ovulation. When the body is chronically stressed or sleep deprived, this hormonal communication can become less favourable for normal reproductive function. Good sleep therefore helps provide the stable physiological environment in which reproductive hormones can work properly.

For women, this is particularly relevant because fertility depends on the precise coordination of hormones such as oestrogen and progesterone throughout the menstrual cycle. Oestrogen rises as the body prepares for ovulation, while progesterone becomes important after ovulation and plays a major role in preparing the uterine lining for a potential pregnancy. Sleep and circadian biology are closely connected to hormonal regulation, so repeatedly staying up late, sleeping at irregular times or consistently getting too little sleep can work against the body’s normal hormonal rhythms. We have a Sleep Guide here if you need to address this lifestyle factor.

Exercise & Movement

Exercise is another important foundation for female fertility, but more is not necessarily better. I recommend around 30 to 60 minutes of exercise most days, partly because regular movement supports mitochondrial health, sleep, mood and stress regulation. Mitochondria are particularly important for reproductive health because eggs require substantial energy during maturation, ovulation and fertilisation. A combination of resistance training, cardiovascular exercise and regular walking is a strong approach. Resistance training helps build muscle and support metabolic health, while cardiovascular exercise improves fitness and insulin sensitivity. Women can benefit from properly performed high-intensity training, rather than spending all their time doing moderate-intensity cardio.

The key is balancing training with enough food and recovery. Very high training loads combined with insufficient energy intake can disrupt menstrual function and potentially affect fertility. The aim is therefore to become stronger, fitter and metabolically healthier without constantly exhausting the body. A sensible fertility-focused routine could include resistance training several times a week, regular walking or moderate cardio, with occasional high-intensity sessions, while making sure the body is adequately fuelled and recovered.

Grounding / Earthing

Grounding, or earthing, means making direct physical contact with the Earth, such as walking barefoot on grass, soil or sand. The theory behind grounding is that contact with the Earth’s surface allows electrons to move between the body and the ground, potentially influencing oxidative stress, inflammation and the body’s electrical environment. For female fertility, the interest centres on inflammation, stress regulation and sleep. Chronic stress and poor sleep can interfere with the hormonal systems involved in reproductive function, while oxidative stress can affect cellular and mitochondrial health. Grounding research has reported improvements in sleep and markers associated with inflammation and stress, making it an intriguing addition to a wider fertility-focused lifestyle.

The simplest approach is also the easiest: spend time outdoors barefoot on natural ground, particularly during the day. Whether walking on grass, sitting on the earth or relaxing barefoot on a beach, grounding combines direct Earth contact with the broader benefits of spending time outside, moving gently and getting natural daylight. It is a simple practice that can complement the more established foundations of fertility such as sleep, exercise, nutrition and stress management. You could also consider a Earthing sheet on your bed, but I think the barefoot method is best.

The Hacks

It’s not possible you are going to or need to do all these things, some will jump out at you, some will feel right. I want you to have everything in one place, I generally find most people have the "I’ll try anything attitude".

Guaifenesin

I actually came cross this on Thai Teds site, been a resource since 2007. I really went down the rabbit hole with this. Guaifenesin is found in your local chemist, or supermarket, it is an expectorant used to loosen mucus in the respiratory system, but there is an interesting fertility application that has been investigated for decades. The reason is simple: cervical mucus plays an important role in conception. Around ovulation, oestrogen naturally changes the mucus produced by the cervix, making it wetter, more abundant, stretchy and easier for sperm to move through. This fertile cervical mucus helps create an environment in which sperm can survive and travel through the cervix towards the egg. A 1982 study published in Fertility and Sterility specifically examined the use of guaifenesin for improving the cervical factor in fertility. The idea is particularly interesting for women who naturally produce thick or limited cervical mucus, or whose cervical mucus becomes less favourable during certain fertility treatments. By helping to loosen mucus, guaifenesin may support the physical environment sperm need to move through the cervix.

The importance of cervical mucus should not be underestimated. It is not simply a fluid surrounding the reproductive system. Around the fertile window, its structure changes to create channels that allow sperm to pass through the cervix, while also supporting sperm survival and transport. Research has found that the characteristics of cervical mucus are associated with the likelihood of conception, which helps explain why improving the quality and quantity of fertile mucus has attracted attention in fertility research. A 2026 randomised controlled trial looked again at oral guaifenesin in women undergoing ovulation induction with clomiphene. The study found that cervical mucus characteristics were associated with pregnancy outcomes, although the researchers concluded that the independent effect of guaifenesin on pregnancy itself remains unclear. This makes guaifenesin particularly interesting as a way of supporting the cervical environment rather than something that directly stimulates ovulation.

The basic fertility concept is therefore fascinating: healthy cervical mucus is part of the body’s natural pathway for getting sperm from the vagina through the cervix and towards the egg. Guaifenesin may help by influencing mucus consistency, potentially making it thinner, more fluid and easier for sperm to navigate during the fertile window. For women interested in optimising every part of their fertility environment, cervical mucus is an often overlooked piece of the puzzle. Take it beginning a few days before ovulation begins and continuing for 4-5 days. It will increase cervical mucus thus increasing the chances the sperm movement. Drink more water at the same time too. I know people who said this worked and one person said they took the Evening Primrose capsules and after sex would put a pillow under my hips and went to sleep. That was the only change she made and it was successful.

Low-Dose Aspirin

I’m not entirely convinced on Aspririn being the best choice but it’s whats worked for many. Low-dose Aspirin reduces platelet aggregation and modulates inflammatory prostaglandins. Reduced platelet clumping improves microvascular blood flow to the uterus. Increased endometrial blood flow enhances oxygen and nutrient delivery to the uterine lining. Aspirin also reduces certain inflammatory markers that interfere with implantation signalling. In women with elevated inflammatory or clotting tendencies, improved uterine circulation increases endometrial receptivity and supports stable embryo attachment. Improved microcirculation enhances implantation conditions during the critical early luteal phase. The dosage is around 81mg daily.

Red Light Therapy for Female Fertility | Lower Abdomen Focus

Red light therapy is awesome, I have huge panel in my spare room. No surprise with all its benefits that it has emerged as a serious tool for women looking to optimise fertility, especially when applied to the lower abdomen and ovaries. Its power comes from cellular-level effects, particularly on mitochondrial function, blood flow, and tissue health. Every reproductive process, egg maturation, ovulation, endometrial preparation, and implantation, depends on energy at the cellular level, and red light directly enhances that energy. When applied to the lower abdomen, it directly energises ovarian and uterine tissue, improves blood flow, reduces inflammation, and supports implantation. For women serious about fertility optimisation, it acts as a cellular-level enhancer that amplifies the effects of nutrition, supplements, and lifestyle interventions. Looking at the body as whole, not individual issues, look at the positive effects below and I’m sure even after you get pregnant and give birth you’ll still want to use Red Light.

Mitochondrial energy boost: Red and near-infrared light penetrate tissue, stimulating mitochondria in ovarian and uterine cells. This increases ATP production, which is critical for egg quality, follicle development, and the function of the endometrial lining. Eggs are highly energy-dependent, and this therapy directly supports their viability.

Improved circulation: By stimulating nitric oxide release and vasodilation, red light enhances blood flow to the uterus and ovaries. Better circulation means more oxygen and nutrients reach reproductive tissues, and waste products are efficiently removed.

Reduced inflammation: Low-level red light modulates inflammatory pathways, helping ovaries and uterine tissues operate in a cleaner, less stressed environment. Chronic inflammation can silently compromise fertility, and this therapy addresses it at a cellular level.

Endometrial support: Enhanced tissue energy and blood flow promote thicker, more receptive endometrial lining, which is essential for implantation.

If you have the funds, get a full size panel you can stand in front of, if you can’t or don’t have space get a small light.

• Target the lower abdomen, just above the pubic bone, aiming to cover the ovaries and uterus region.
• Sessions of 20 minutes, at least 4 times per week, this is typically effective for fertility optimisation.
• Consistency over weeks to months is key, the effects are cumulative rather than immediate.
• Can be combined with abdominal fertility massage, I’ll explain more on this below or other circulation-focused therapies.

Chiropractic Sessions

This is helpful in my opinion for nervous system regulation. The spine houses the nerves that connect the brain to the ovaries, uterus, and endocrine glands. Misalignments, especially in the lower spine and sacrum, can create subtle nerve interference. Chiropractic adjustments can improve signalling between brain and body, which helps normalise hormone communication. It also supports pelvic alignment and blood flow. So if the pelvis is even slightly misaligned, it can reduce optimal blood flow to the reproductive organs. Better alignment can improve circulation to the uterus and ovaries, which matters for ovulation, egg nourishment, and endometrial development.

Although I will always say stopping stress starts in the mind, by letting go, releasing and the power of now, still it’s fair to say a session can support that, so stress and cortisol reduction. Chiropractic care often shifts the body out of a sympathetic “fight or flight” state into a more parasympathetic “rest and repair” mode. High cortisol directly suppresses reproductive hormones, so lowering stress physiology can indirectly support fertility. Then there’s the positive effect on cycle-related tension and discomfort. Some women have chronic tension patterns in the lower back, hips, or abdomen that correlate with painful or irregular cycles. Releasing these patterns can improve overall reproductive function.

Acupuncture

I am a fan of Acupuncture, I went to China in 2012 and there I saw for my own eyes, that people all over use it with incredible success. Obviously I didn’t use it for fertility but I have now looked into it for female fertility. My research leads me to see it enhances the rate of conception, in general acupuncture is creating a balanced environment ideal for pregnancy. It reduces anxiety, promoting emotional well-being and a relaxed state beneficial to fertility. Actually the benefits extend past this, addressing hormonal balance, reproductive function, and mental resilience. I still say to people that come in store with all issues, if you have the time and money get a few acupuncture sessions whatever the issue. But the real key is to research to find a reputable real one. I know first hand through a friend that there are a lot of scammers out there and have shops people walk into.

Anyway you would find a decent practitioner, Nigel at Synergy by Ancient Purity is the man, he helped me after I was hit by a car in 2015. But this is obviously over here in the South East of England. Find a good one close to you. The why is simple, because acupuncture improves fertility by increasing blood flow to reproductive organs, enhancing egg development, and uterine receptivity. It regulates hormones through hypothalamic stimulation, supporting ovulation, follicular development, and embryo implantation. Also it’s helpful to men, I know I’m talking for women here but I do have the Male Fertility Guide too. In men acupuncture boosts sperm count and quality. You’d get personalised treatments with whoever you find, that will help balance hormones and improve reproductive health. Many patients report better cycles and outcomes with regular sessions. There’s no downside to acupuncture, I strongly suggest you add it in.

Fertility Massage (Abdominal / Maya / Womb Massage)

This is one of the few hands-on therapies that directly targets the reproductive organs and surrounding tissues, rather than just influencing general wellness. Its core power comes from improving blood flow, lymphatic drainage, and tissue mobility in the pelvic region. Many women carry subtle restrictions, adhesions, or tension in the uterus, ovaries, or supporting ligaments—sometimes from prior inflammation, minor infections, or even scar tissue—that can silently reduce circulation and impair fertility. Through skilled, targeted manipulation, fertility massage:

• Enhances circulation to the uterus and ovaries, delivering oxygen, nutrients, and hormones where they are most needed for egg maturation and endometrial health.
• Improves uterine alignment and mobility, ensuring the uterus sits optimally and is free to expand and contract naturally, which can improve implantation chances.
• Breaks up fascial restrictions or adhesions that may restrict tissue movement or create micro-stagnation in the reproductive organs.
• Supports lymphatic flow, helping remove metabolic waste and excess hormones from the pelvic area, reducing inflammation and creating a cleaner environment for conception.
• Reduces stress and nervous system tension, especially in the lower abdomen and pelvic floor, which allows reproductive signalling to function more efficiently.

The effects are cumulative, regular sessions over several weeks or months can transform the uterine environment, making it thicker, more responsive, and more receptive. For women struggling with poor implantation, irregular cycles, or mild pelvic adhesions, fertility massage is one of the most tangible ways to physically optimise the reproductive system. It’s a precision tool, not a general wellness massage, and is most effective when combined with circulation-boosting lifestyle measures like acupuncture, abdominal blood flow exercises, and nutritional support. I personally think if you have the time, or more importantly are going to make the time, this is worth adding in. Then there’s the touch affect. This is the reason I don’t write that many Guides, as I start one and each can lead into several more on every little thing in them.

Peptides

I put peptides last because they’re a little outside of natural health, some say they are natural, I could say they’re synthetic, but of things natural, It’s not my place to call it really. I’m the owner of Ancient Purity, I don’t sell peptides but I know of many outstanding results with them. You also would have to inject them to get the real affects, and there are those with good reason in natural health who would say don’t use needles. Again it’s not my call, would I use them? Yes I would and I have to date I’ve tried BPC 157, TA1 and MOTS C, but I haven’t used any in a year, BPC157 was awesome TA1 great, MOTS C I noticed nothing myself, but I know have had results for others. Your goal here is to get pregnant right?, you have tried everything and if you are reading this whole Guide and saying, done that, done that. In which case, you could be one of those that wants to dive into peptides. So here’s what I have read and synthetic or natural, this is what they do. If you want to progress with any I would do research for yourself on how much to take and how often.

Kisspeptin… The Game-Changer for Female Fertility

Kisspeptin is one of the body’s key reproductive signalling molecules. It acts through the kisspeptin receptor, KISS1R, on GnRH neurons in the hypothalamus. When kisspeptin activates this system, it stimulates GnRH release, which then drives the pituitary to release the gonadotropins LH and FSH. These hormones act on the ovaries to support follicular development, oestrogen production, maturation of the dominant follicle and ultimately ovulation.

One of the most important roles of kisspeptin is its involvement in the LH surge that triggers ovulation. During the late follicular phase, rising estrogen changes its feedback effect on the brain. Kisspeptin neurons become strongly activated, increasing GnRH signalling and producing the powerful LH surge required for final maturation of the egg and ovulation. In other words, kisspeptin is positioned directly upstream of one of the most important events in the entire menstrual cycle. Human studies have shown that administering kisspeptin can stimulate LH release and increase reproductive hormone activity, including in women with hypothalamic amenorrhoea. Kisspeptin therefore provides a way of activating the reproductive axis from the brain rather than simply supplying reproductive hormones from outside the system.

Kisspeptin also has an important connection with FSH and follicular development. GnRH pulsatility determines the balance of LH and FSH secretion, and that pattern changes throughout the menstrual cycle. FSH supports the development of ovarian follicles, while LH contributes to steroid production and the later events leading to ovulation. Because kisspeptin helps regulate the GnRH pulse generator, it sits at the beginning of this communication network, helping coordinate the hormonal sequence rather than acting on only one isolated part of it.

There is also growing interest in kisspeptin within the ovary itself and during assisted reproduction. Research has found associations between kisspeptin levels in follicular fluid and successful IVF outcomes, and laboratory research has shown kisspeptin can enhance aromatase expression in human granulosa-like cells in the presence of FSH and IGF-1. Aromatase is involved in estrogen production, making this another fascinating connection between kisspeptin signalling and ovarian steroid production.

Perhaps the most developed fertility application is using kisspeptin as an ovulation and egg-maturation trigger during IVF. Unlike hCG, which acts further downstream, kisspeptin works through the natural hypothalamic GnRH pathway. Clinical research has demonstrated that kisspeptin administration can generate an LH surge and trigger final oocyte maturation. This has attracted particular interest because kisspeptin-based triggering can potentially reduce the risk of ovarian hyperstimulation syndrome in women undergoing fertility treatment.

What makes kisspeptin so powerful conceptually is its position in the reproductive hierarchy. It connects information about estrogen, metabolic status, energy availability and the body’s broader physiological state with the reproductive system. The kisspeptin network, together with neurokinin B and dynorphin, helps generate the rhythmic GnRH signalling required for normal reproductive function. This gives the reproductive system a sophisticated central control mechanism that can coordinate ovarian activity with the body’s overall condition.

For female fertility, the significance is therefore much bigger than simply saying that kisspeptin increases LH. Kisspeptin is part of the central command system controlling GnRH, LH, FSH, estrogen signalling, follicular development, the LH surge, egg maturation and ovulation. That is why it has become such an important area of reproductive medicine research and why kisspeptin-based treatments are being investigated for conditions involving disrupted reproductive signalling, including hypothalamic amenorrhoea and certain forms of anovulation. The most compelling way to understand kisspeptin is that it is one of the body’s master reproductive signals, sitting upstream of GnRH and helping initiate the hormonal cascade that ultimately produces ovulation.

MOTS-C

MOTS-C is a 16-amino-acid peptide encoded by mitochondrial DNA and acts as a signalling molecule involved in cellular metabolism, insulin sensitivity, energy regulation and the body’s response to metabolic stress. Perhaps one of the strongest fertility connections is metabolic. Ovarian function is highly energy dependent, while insulin resistance and metabolic dysfunction can interfere with reproductive signalling and ovulation, particularly in PCOS. MOTS-C has been studied for its effects on insulin sensitivity and metabolic health, with experimental research showing improvements in glucose regulation and metabolic function. This becomes particularly interesting in PCOS. Research has found reduced MOTS-C levels in women with PCOS, alongside evidence of mitochondrial dysfunction. This provides an important connection between MOTS-C , mitochondrial biology and the metabolic abnormalities associated with PCOS.

MOTS-c also activates AMPK, one of the body’s major cellular energy sensors. AMPK helps cells respond to their energy requirements and regulates glucose and fat metabolism. By influencing this pathway, MOTS-C has shown effects on insulin sensitivity and metabolic resilience in experimental research. Since healthy insulin sensitivity is important for normal ovarian function and ovulation, this metabolic pathway is one of the reasons MOTS-C has attracted attention in reproductive research. There is also growing interest in MOTS-C and ovarian ageing because eggs are exceptionally energy-demanding cells and rely heavily on their mitochondria. Research into mitochondrial-derived peptides is exploring whether these molecules can improve cellular resilience, energy production and resistance to age-related metabolic dysfunction.

What makes MOTS-C particularly interesting is its position at the intersection of mitochondrial function, glucose metabolism, insulin sensitivity, energy availability and cellular stress responses. This makes it very different from kisspeptin. Kisspeptin directly influences the reproductive signalling pathway controlling GnRH, LH, FSH and ovulation, whereas MOTS-C is focused more on the metabolic and mitochondrial environment supporting reproductive function. For female fertility, MOTS-C is therefore best understood as a potential metabolic and mitochondrial fertility pathway, with particular interest around insulin resistance, PCOS, mitochondrial health and cellular energy. The combination of these systems makes MOTS-C one of the more intriguing areas of peptide research in reproductive health.

Neurokinin B NKB

NKB is particularly interesting because it works as part of the same reproductive signalling network as Kisspeptin. Within the hypothalamus, neurokinin B helps regulate the rhythmic activity of the neurons responsible for GnRH pulses. Those GnRH pulses then control the pituitary release of LH and FSH, which drive ovarian follicle development, estrogen production and ovulation. Neurokinin B is therefore involved in the timing and rhythm of the reproductive system rather than simply producing a single hormonal response. The kisspeptin, neurokinin B and dynorphin network, often referred to as the KNDy system, is considered a central component of the machinery controlling reproductive hormone signalling. This makes NKB particularly interesting in conditions where GnRH and LH signalling becomes disrupted. Research is also investigating NKB signalling in PCOS, endometriosis and other reproductive disorders.

GnRH Gonadotropin-releasing Hormone

GnRH is one of the central hormones controlling female reproduction. It is released from the hypothalamus in pulses and travels to the pituitary, where it stimulates the release of LH and FSH. Those two hormones then act on the ovaries to coordinate follicle development, estrogen production and ovulation. The fascinating part is the importance of the pulse pattern. GnRH is not simply switched on continuously. The frequency and timing of its pulses help determine how the pituitary produces LH and FSH throughout the menstrual cycle. A properly functioning GnRH system therefore sits directly at the heart of the communication between the brain and the ovaries. Because of this, pulsatile GnRH has an established place in reproductive medicine and can be used to stimulate ovulation in women whose fertility problems involve inadequate hypothalamic GnRH signalling. It represents one of the most direct ways of restoring the hormonal communication required for ovulation.

IGF-1 Insulin-like Growth Factor 1

IGF-1 is an important growth and metabolic signalling molecule with a significant role in ovarian function. Within the ovary, IGF-1 works alongside FSH and other growth factors to support granulosa-cell activity, follicular development and oestrogen production. This makes IGF-1 interesting because developing follicles are highly active biological structures requiring substantial communication between hormones, growth factors and metabolic pathways. IGF-1 contributes to this environment and can enhance the actions of FSH within the follicle. IGF-1 also connects reproductive health with overall metabolic health. Adequate energy availability and normal insulin signalling influence the IGF system, creating a link between nutrition, metabolism and ovarian function. The IGF-1 pathway is therefore part of the wider network helping follicles grow, mature and become capable of supporting ovulation.

Anti-Müllerian Hormone AMH

AMH, is produced by developing ovarian follicles and has become one of the most useful biological markers of ovarian reserve. AMH gives an indication of the population of small growing follicles within the ovaries and is therefore particularly valuable when assessing ovarian function and reproductive potential. AMH is different from Kisspeptin or GnRH because it is not primarily a hormone used to trigger ovulation. Instead, it provides information about the ovarian follicle pool and how the ovaries are functioning. It can be measured through a blood test and is frequently used alongside antral follicle count and other fertility assessments. AMH is particularly useful because it can provide information about ovarian reserve without depending heavily on the particular day of the menstrual cycle. It can also help clinicians understand how the ovaries may respond to stimulation during assisted reproduction. In that sense, AMH is less about pushing fertility harder and more about understanding the reproductive capacity of the ovaries.

Leptin

Leptin provides an important connection between energy availability and reproductive function. It is produced largely by adipose tissue and communicates information about the body’s energy stores to the brain. The reproductive system pays close attention to this information because reproduction requires sufficient energy and resources. Leptin interacts with hypothalamic pathways involved in reproductive signalling, including the Kisspeptin and GnRH systems. When adequate energy is available, these signals help support normal reproductive function. When energy availability becomes too low, reproductive signalling can be suppressed, which is one reason significant undernutrition or excessive energy expenditure can interfere with menstrual function. This makes Leptin an option in women experiencing reproductive disruption associated with low energy availability. Rather than being simply a fat-storage hormone, leptin acts as part of the communication system telling the brain whether the body’s energy reserves are sufficient to support reproduction.

Ghrelin

Ghrelin is often described as the body’s hunger hormone, but its influence extends into the reproductive system. Produced primarily in the stomach, ghrelin communicates information about energy availability to the brain and interacts with the hypothalamic systems controlling reproduction. Ghrelin has an important relationship with GnRH signalling, helping demonstrate how closely appetite, metabolism and fertility are connected. When the body is experiencing an energy deficit, changes in ghrelin and other metabolic signals can influence the reproductive axis. Ghrelin is perhaps more the whole-body perspective. The reproductive system is constantly receiving information about nutrition, energy availability and metabolic status. Ghrelin is one of the molecules involved in that conversation, linking the body’s nutritional state with the brain’s control of reproductive hormones.

After over a year coming back and forth to this article, as of it’s release now in September 2026 I will be taking a break from female fertility research but if I come across anything, rest assure it will be updated, at least if you are reading this in 2027 or onwards. Remember the solutions are usually ancient, the basics don’t change. Wishing you luck, health and happiness, Tom.